In vitro determination of the anti-aging potential of four southern African medicinal plants
نویسندگان
چکیده
BACKGROUND Aging is an inevitable process for all living organisms. During this process reactive oxygen species generation is increased which leads to the activation of hyaluronidase, collagenase and elastase, which can further contribute to skin aging. Four southern African medicinal plants; Clerodendrum glabrum, Schotia brachypetala, Psychotria capensis and Peltophorum africanum, were investigated to assess their anti-aging properties. METHODS Anti-elastase, anti-collagenase and anti-hyaluronidase activities of twenty-eight samples, consisting of methanol and ethyl acetate extracts of the four plants, were determined using spectrophotometric methods. Radical scavenging activity was determined by the ability of the plant extracts to scavenge the ABTS•+ radical. RESULTS The majority of the samples in the anti-elastase assay and nine in the anti-collagenase assay showed more than 80% inhibition. The ethyl acetate extract of S. brachypetala bark and leaves of P. capensis inhibited elastase activity by more than 90%. The methanol extract of S. brachypetala bark contained the highest anti-hyaluronidase activity (75.13 ± 7.49%) whilst the ethyl acetate extract of P. africanum bark exhibited the highest antioxidant activity (IC50: 1.99 ± 0.23 μg/ml). CONCLUSION The free radical scavenging activity and enzyme inhibitory activity of the plant extracts investigated suggests that they can help restore skin elasticity and thereby slow the wrinkling process. P. africanum was the plant with the most promising activity and will be subjected to further testing and isolation of the active compound/s.
منابع مشابه
In vitro Anti-epimastigote Activity of some Iranian Medicinal Plants
Some medicinal plants are a potential source of new drugs, in order to improve the treatment of Chagas disease whose treatment is still a challenge. In this study, the in vitro anti-epimastigote activity of certain fractions of Achillea biebersteinii, A. millefolium, Satureja mutica and S. macrantha was evaluated. Diethyl ether fractions of Achillea species and acetone fractions of Satureja spe...
متن کاملIn vitro Anti-epimastigote Activity of some Iranian Medicinal Plants
Some medicinal plants are a potential source of new drugs, in order to improve the treatment of Chagas disease whose treatment is still a challenge. In this study, the in vitro anti-epimastigote activity of certain fractions of Achillea biebersteinii, A. millefolium, Satureja mutica and S. macrantha was evaluated. Diethyl ether fractions of Achillea species and acetone fractions of Satureja spe...
متن کاملEvaluation of sun protection activity of some medicinal herbs extracts
In vitro evaluation of sun protection activity of some medicinal herbs by SPF determination, to find out which herbal extracts have the best protection activity and can be used as sunscreen agent. Sun rays are the most environmental harmful factor which affect skin, cause sun burn and photo aging. According to the previous studies the plant’s flavonoids are suitable absorbents for UV rays. In t...
متن کاملEvaluation of sun protection activity of some medicinal herbs extracts
In vitro evaluation of sun protection activity of some medicinal herbs by SPF determination, to find out which herbal extracts have the best protection activity and can be used as sunscreen agent. Sun rays are the most environmental harmful factor which affect skin, cause sun burn and photo aging. According to the previous studies the plant’s flavonoids are suitable absorbents for UV rays. In t...
متن کاملAnti-Aging Effects of Some Selected Iranian Folk Medicinal Herbs-Biochemical Evidences
Objective(s): In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. Materials and Methods: Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500 mg/kg/day for 6 weeks). A positive control group was assigned...
متن کامل